| The study aims to apply the therapeutic drug monitoring to measure first and second line drug levels in MDRTB patients and to evaluate the benefits of TDM related to pharmaceutical care including,effectiveness of therapy,adverse drug reactions, and patient compliance.The study is a quasi-experimental design. the volunteers were patients diagnosed for MDRTB and be treated at Sapasithiprasong Hospital and TB Clinic of Department of Prevention and Control, Region 7, Ubon Ratchathani province. They have been taking both pyrazinamide and cycloserine for their treatments. There are 11 study and 13 controlled volunteers enrolled into the study.
The findings showed PZA and cycloserine levels measured from both blood samples and calculation were normally similar, except in some circumstances including, the difference between blood sampling and medication taking times, patient non-compliance, renal and liver malfunctions. Regarding the assessment of TDM related to the effectiveness of therapy, it might explain the further benefit of TDM to evaluate whether the medications can potentially be effective to MDRTB. Finally, the TDM can potentially help health care providers to monitor patient compliance via the panel of drug levels over period of time.
Conclusively, therapeutic drug monitoring showed the benefits for health workers to evaluate the efficacy of MDRTB treatment as well as adverse events and patient compliance. Even there still are some limitations stated in the study including, a short duration of data collection, a limit number of volunteers, etc. |