Abstract

Title : ACCELERRATED STABILITY TESTING OF EXTEMPERANEOUS SUSPENSION OF ACETAZOLAMIDE, FUROSEMIDE, AND PHENYTOIN
By : SALINEE NA RANONG SIRILAK RAKROD
Degree : BACHELOR OF PHARMACY
Advisor : WARISADA SILA-ON ZONGPORN JOUNGMUNKONG
Keywords : ACETAZOLAMIDE, FUROSEMIDE, EXTEMPORANEOUS PREPARATION, POWDER FOR SUSPENSION, STABILITY
   
The purpose of this work was to investigate the physical and chemical stability of the extemporaneous preparations of 10 mg/ml Acetazolamide (AM), 2 mg/ml Furosemide (FM) and 2 mg/ml Phenytoin (PT) in terms of powder for suspensions, to verify their tentative shelf-life and appropriate storage condition. All preparations (powders and suspensions) were kept for 4 months at 4°C, 25°C/75% RH, 45°C/75% RH, and ambient temperature. The change in physical characters such as color and pH of suspensions were determined. The remained drug contents were analyzed using HPLC technique at the initial and the period of testing. It was found that pH and remained content of AM powder for suspension was unchanged at all conditions while that of suspensions was decrease when keeping at 45 C/75% RH for 4 months. For both dosage forms of FM, no change in pH and % drug remaining contents were more than 90% were observed at all condition throughout the study period. Powder for suspensions and suspension of PT, pH was unchanged in all conditions. But the remaining contents were more than 90% for a month keeping. From data obtained, it could be concluded that powder dosage form of AM was more stable than suspensions and should be kept at 4 or 25°C. The desirable storage conditions of both FM extemporaneous preparations were 4, 25°C or ambient temperature. The tentative shelf-life of powder for suspensions of AM and FM is probably 12 months because of no change in the physical and chemical qualities when carrying at 45°C/75% RH for 4 months. But the powder for suspension and suspension of PT could be kept at 4, 25°C or ambient temperature for a month. However the microbial stability and preservative effectiveness tests should have been include in this study in order to ensure the efficacy and safety of drug use.
   
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