| Clotrimazole is an antifungal agent that commonly used in the treatment of fungal infections. But it is a poorly water-soluble drug. In recent years much attention has been focused on self-emulsifying drug delivery systems to improve oral bioavailability of poorly water-soluble drugs. However, there is a few limitations associated with this delivery system, including stability, manufacturing methods, interaction of the fill with the capsule shell in this study we intend to prepare solid SEDDS by foam-mat drying technique with foaming agents and inert solid carrier. SEDDS of clotrimazole consisted of polysorbate 80, oleic acid and medium chain triglyceride (MCT) which contained clotrimazole 40 mg/mL. Albumin powder, soybean protein and hydroxypropyl methylcellulose 4000 (HPMC 4000) were used as the foaming agent. Foaming agents and solid carrier were mixed with liquid SEDDS of clotrimazole by homogenizer until foam was formed and then dried in hot air oven or vacuum dryer at 60 oC for 24 hours. Appropriate dried foam was mixed with the diluents and filled in capsules. In vitro dissolution study was carried out by dissolution apparatus II using 0.1 N hydrochloric acid as a medium and drug dissolved was quantified with HPLC. The dissolution of foam-mat dried formulation consisted of SEDDS 20% and 10% with 10% soybean protein demonstrated about 48.93% and 18.91%, respectively. Those with 10% albumin showed 8 and 12%, respectively. In addition, in DSC thermogram no peak of drug was observed indicated that clotrimazole was completely dissolved in SEDDS resulting in improving its dissolution. |