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Abstract |
| Title |
: STUDY OF CEFAZOLIN ENTRAPMENT AND RELEASE OF HYDROGEL PATCH FROM NATURAL RUBBER AND
MODIFIED STARCH |
| By |
: MEENRAYA SOMDANGCHAI WAYOON KLANGPHAPAN PAWORNRAT POUNGSIRI |
| Degree |
: DOCTOR OF PHARMACY |
| Advisor |
: UTSANA PUAPERMPOONSIRI WARISADA SILA-ON |
| Keywords |
: CEFAZOLIN, HYDROGEL, NATURAL RUBBER, MODIFIED STARCH, PATCH, ENTRAPMENT, RELEASE |
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| Drug entrapment and release studies are needed for the development of cefazolin hydrogel-transdermal patch comprising of natural rubber and modified rice/banana starch (mRSt/mBSt). Since the different types of starch provide the different water absorption property. This study aimed to determine the entrapment and release of cefazolin from hydrogel patch comprising of crosslinked natural rubber and modified rice/banana starch. Direct addition method was employed for cefazolin entrapment with 3 different initial concentrations (1, 10, and 100 µg/ml) within 24 hours. High Performance Liquid Chromatography (HPLC) was utilized for cefazolin quantitative analysis. Physical properties such as water absorption, swelling and weight loss of polymer were also investigated. The results showed that the initial concentration 100 μg/ml was able to use for loading cefazolin in this system. The patch containing mBSt provided a greater cefazolin entrapment than the patch containing mRSt (393.84 μg and 290 μg, respectively). As the release profile, it showed that constant rate of release was seen for natural rubber patch (without starch) at 4 hours onward. Whereas the amount of drug in the patch containing mRSt provided more release than in patch containing mBSt (the initial drug release 122.31% and 85.90% within 4 hours, respectively) and slowly released after 4 and 24 hours. Percent cumulative drug release at 24 hour was also determined. It showed that patch containing mRSt and mBSt provided 184.3 and 133.13 %, respectively. Conclusively, direct addition method was successfully used for cefazolin in hydrogel-transdermal patch comprising of natural rubber and modified rice/banana starch by the initial loading concentration 100 μg/ml. Cefazolin was also able to release 133-184% within 24 hours. As the release concentration, it was effective dose for S. aureus infection treatment (release concentration > MIC). To obtain higher drug release, higher drug loading initial concentration are required in further study. There should study cefazolin releasing profile from the hydrogel at higher concentrations. |
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