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Abstract |
| Title |
: DEVELOPEMNT OF THEOPHYLLINE EFFEERVECENT DRY POWDER FOR PULMONARY DRUG DELIVERY PHASE III |
| By |
: THEERAWOOT SEETAWUN , PRATCHAPON TARNSUWAN AND WUTCHARA JUNKHEIW |
| Degree |
: DOCTOR OF PHARMACY |
| Advisor |
: JINTANA NAPAPORN |
| Keywords |
: THEOPHYLLINE, EFFERVESCENT DRY POWDER, PULMONARY DRUG DELIVERY, SPRAY-DRYING |
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| The objective of this current study was to develop theophylline effervescent dry powder for pulmonary drug delivery. The effervescence technique combined with spray-drying technique was utilized as the means to improve water solubility and hygroscopic properties of theophylline. There here formulations developed in this study, i.e. Conventional Theophylline Dry Powder, Effervescent Base Dry Powder, Theophylline Effervescent Dry Powder and Theophylline Effervescent Dry Powder + PEG. The hygroscopic properties, polymorphism change, solubility and content analysis of those formulations were assessed. The effervescence technique combined with spray-drying technique proved to be able to produce dry powder for inhalers. However the characteristics of those spray-dried powders showed to be very hygroscopic. In order to reduce its hygroscopicity and improve particle dispersion, PEG 1500 and PEG 4000 were incorporated into formulations. The results had shown that PEG 1500 (5 and 10%) was effective to improve spray-dried powder characteristic. The preliminary solubility test had shown that Theophylline Effervescent Dry Powderdissolved fastest in water and Theophylline Effervescent Dry Powder + PEG dissolved slowest.Thepolymorphism of all formulation prepared by spray-drying technique was amorphous form. Content analysis of theophylline in those formulationswas in the range of 95.40 – 104.51%. |
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