Abstract

Title : HEMATOLOGIC TOXICITIES OF CONCURRENT CHEMORADIATION IN CANCER PATIENT AT UBONRATCHATHANI CANCER HOSPITAL
By : TASSAWAN ITIPISO WATCHARIN THANGTONG
Degree : DOCTOR OF PHARMACY
Advisor : MANIT SAETEAW THANUT KHUAYJARERNPANISHK SISIRA DONSAMAK
Keywords : CONCURRENT CHEMORADIATIO (CCRT), ANEMIA, LEYCOPENIA, NEUTROPENIA, THROMBOCYTOPENIA
   
Concurrent Chemoradiation is an important strategy which is recommended in treatment many types of cancer. Hematologic toxicities from Concurrent Chemoradiation which is an important drug-related problem are gradually reported. Objectives= The purpose of this study was to evaluate the prevalence of hematologic toxicities of Concurrent Chemoradiation in cancer patients at Ubonratchathani Cancer Hospital Methods= The Cross – sectional retrospective study was conducted based on medical records of 127 cancer patients who were treated with Concurrent Chemoradiation between January and June 2012 at Ubonratchathani Cancer Hospital. Prevalence of grade 3-4 hematologic toxicities including Anemia, Leucopenia, Neutropenia and Thrombocytopenia were collected from computerized data base. The result was analyzed by Descriptive statistic. McNemar chi-square test and T-test were applied to compare prevalence of hematologic toxicities after Concurrent Chemoradiation. Results= The study showed that the prevalence of hematologic toxicities significant increased from 85..8% to 99.2% (P<0.05). Grade 3-4 toxicities were found 16.5% in the patients. Among patients who got hematologic toxicities, 98.4% were anemia (4.7% grade 3-4), 70.8% were leucopenia (11.8% grade 3-4), 41.7% were neutropenia (4.7% grade 3-4) and 22% were thrombocytopenia (no grade 3-4). Conclusions = The prevalence of grade 3-4 hematologic toxicities increased after treated with Concurrent Chemoradiation.
   
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