Abstract

TITLE    : DEVELOPMENT OF ORAL DISINTEGRATING TABLETS USING                                  SUBLIMATION TECHNIQUE WITH MICROWAVE IRRADIATION                             BY                       : PANUPONG BUAKAEW AND SIWAT SARA                                             DEGREE           : DOCTOR OF          PHARMACY                                                                             MAJOR             : PHARMACEUTICAL  SCIENCE                                                                                      CHAIR         : ASST. PROF. DR. WARISADA SILA-ON                                                                 ASST. PROF. DR. UTSANA PUAPERMPOONSIRI                                                            AND DR. SUREEWAN DUANGJIT                                                        KEYWORD           : Oral Disintegrating Tablets , Sublimating agent , Microwave irradiation                  Introduction: Oral Disintegrating Tablets (ODTs) with good performance are able to disintegrate within 10 seconds, but they are high porosity and fragile. They need to use the expensive special package. So that, several attempts has been to investigated produce the desirable hardness and simple producing process. Objective: To study the influence of sublimating agents and contact time of microwave irradiation to tablets on the characteristics of treated ODTs. Method: ODTs composed of Diclofenac sodium (25mg), sweetening agent (10mg), sublimating agents such as ammonium bicarbonate (10mg) and diluents including microcrystalline cellulose and xylitol, which adjusted to 250mg of tablet weight. Compressed to tablet with hydraulic compactor and then treated with microwave oven at power of 900 watts for 3.30, 6.30, 10, 15 and 20 min. The characteristics of tablets including hardness, friability, disintegration time and in vitro dissolution were determined. Results: The desirable characters of ODTs were  5.05±0.55kg of hardness with fasting disintegration of 72.17±25.17  seconds. They consisted of ammonium bicarbonate and xylitol as sublimating agent and diluent, respectively, and treated to microwave irradiation for 3.30 min. Conclusion: Heat generated from microwave irradiation caused the sublimating agent sublimed and produced the porosity within tablets, while sugar alcohol as diluent was melted resulting in the increasing of tablet strength. These provided the appropriate characteristic of tablets.