Abstract

Title : INCIDENCE RATE OF DEPRESSION IN PATIENT WITH TYPE 2 DIABETES MELLITUS
By : PONGSAGORN MANISSORN AND PHOOWANAT SATPRASIT
Degree : DOCTOR OF PHARMACY
Advisor : ASST. PROF. DR. SAWAENG WATCHARATHANAKIJ AND ASST. PROF. APORN JATURAPATTARAWONG THANATCHA SONGMUANG
Keywords : TYPE 2 DIABETES MELLITUS, DEPRESSION
   
Depression is one of common comorbidities in type 2 diabetic patients. Management of depression in these patients must be carried out because it can lead to negative consequences such as diabetic complications, morbidity and mortality. This retrospective cohort study aims to measure the incidence rate of depression in type-2 diabetes mellitus patients. Methods= Newly diagnosed DM patients from 1/01/2007 to 31/12/2009 were recruited by ICD-10 of Diabetes type 2 (E11) and followed up to 31/12/2014. Follow-up time is approximately 5 years for each patient. Depression were defined as T2DM patients who were diagnosed with ICD-10; F32-F33 or (2) received antidepressive medications; fluoxetine or sertraline at least 3 months or (3) having symptoms associated with depression by 2Q-9Q questionnaire. Results= Of 1,471 newly diagnosed DM patients, incidence rate of comorbid depression is 13.59 per 1000 person-years (95% CI = 11.37-16.24). Incidence rates of depression in women and men are 14.25 per 1,000 person-years (95% CI = 11.40-17.82) and 12.57 per 1,000 person-years (95% CI = 9.35-16.89), respectively. Incidence rate in DM patients with different treatment regimen, which are oral antidiabetic medications only, insulin only, and both, are 15.33 per 1,000 person-years (95% CI = 12.42-18.18), 7.02 per 1,000 person-years (95% CI = 3.89-12.67), and 14.14 per 1,000 person-years (95% CI = 5.31-37.68), respectively. Conclusion= Conclusively, incidence rate in type 2 diabetes mellitus patients has found higher than normal group of population. It is recommended that psychological tests should be performed in type 2 diabetes patients routinely
   
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