| Beta-glucans is a natural compound found in several kinds of foods such as some mushrooms. Many reports also demonstrated the immune-modulating effect and anti-inflammatory activity of beta-glucan. The inflammation relates to the severity of gout symptom thus it is possible to use beta-glucan to relive the inflammation of gout disease. Objective= This study aims to develop the formulation of mushroom tablets for medical application. Methods= Pre-formulation of 3 types of mushroom powders (Lentinus edodes, Pleurotus ostreatus and Pleurotus pulmonarius) was performed and direct compression method with 500 mg per tablet at 60 MPa was used in this study. The effects of the additives such as absorbent (Aerosil®, silicon dioxide) and disintegrant (Avicel® PH102, microcrystalline cellulose PH102) at concentration 0.1-1 % and 3-4 %, respective, on the characteristic of mushroom tablets were investigated. All tablets were evaluated following the quality control guideline of United State Pharmacopeia 36 (USP 36) for example weight variation, friability, disintegration time, hardness and thickness. Results= As the pre-formulation results, mushroom powders were demonstrated the moisture content less than 10 percent (%LOD < 10%). The flow ability of mushroom powders was poor since the angle of repose and compressibility index were in range 36.82-48.59 and 21.69-34.29, respectively. Mixed mushroom without additives was able to form a tablet with high friability and high disintegration time (greater than 30 min). Fortunately, the addition of 0.1% Aerosil® and 3.9% Avicel® PH102 was helpful for the characteristic of mixed mushroom tablets. Following the additives addition, the friability was low (0%) and disintegration time of tablets was less than 30 minutes. Conclusions= Conclusively, direct compression method is able to used for mixed mushroom tablets formulation. The additives such as of Aerosil® and Avicel® PH102 have been used as the absorbent and disintegrant, respectively. |