| Kha-ling (Alpinia conchigera) is plant commonly used as food and medicine. Its antioxidant activity in vitro experiments have been reported. This research aims to study the antioxidative effect of Kha-ling extract in male rats aged 6 wks on oxidative stress induced by carbon tetrachloride (CCl4). CCl4 (0.3 ml/kg) were intraperitoneally injected at day 14 or day 28 to rats orally received solvent, Kha-ling extract (100, 200 or 500 mg/kg) or vitamin E (300 mg/kg) consecutively for 28 days. At the end of experiment, the blood, liver, brain were harvested and prepared for ALT, AST, ALP, and MDA content assay. These variables were compared between groups. The results demonstrated that ALT, AST, ALP, and MDA level of solvent control rats were significantly higher than those of normal rats after receiving CCl4 on day 14 or day 28 (p<0.05). Vitamin E reduced the ALT, AST, ALP, and MDA levels compared with solvent control rats as well as with rats received Kha-ling extract in all tested doses. Compare the level of all variables between rats received tested compounds consecutively for 28 days but were injected with CCl4 at day 14 with day 28, the level plasma enzymes and plasma, liver, and brain MDA in rats injected with CCl4 at day 14 were lower than those of rats injected with CCl4 at day 28. |