| Centella asiatica (Linn.) Urban has been widely used as Thai folk medicine. Objective The purpose of this study was to determine the physical and microbiological stability of Centella capsule. Method Centella asiatica (Linn.) Urban from Ubonratchathani province was used. Only the leaves were collected and washed before drying at 50oC for 72 hours. Grinded and passed through to sieve number 100, then flowability and moisture content of Centella powder were performed. Centella powder was filled into capsule number 0 using capsule filling machine. The physical character of Centella capsule was determined as weight variation, disintegration time. For microbiological tests, Total aerobic microbial, yeasts and molds count, and test for inspection of 4 prohibited microbes, namely S. aureus, E.coli, Salmonella spp., and Clostridium spp. were performed. Centella capsules were kept in temperature of 25oC and 45oC with relative humidity of 75% for 6 months. Result Centella powder showed a good flowabilty with loss on drying of 7.70% which passed the requirement according to THP supplement 2004. Weight variation and disintegration time of Centella capsule passed the standard of USP 36. For the examination of microbiological test of Centella capsules keeping at 25oC and 45oC with 75 %RH for 6 months, Total aerobic microbial, yeasts and molds count did not meet the requirement of THP 2000 and It is inconclusive whether or not by those 4 prohibited microbes. Conclusion Raw material of Centella capsule should be treated to eradicate microorganism before manufacturing and finished goods in order to keep quality and safety of consumer. |