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Abstract |
| Title |
: DEVELOPMENT OF SKIN PATCH FROM XYLOGLUCAN CONTAINED CAPSICUM EXTRACT FOR PAIN RELIEF.DEVELOPMENT OF SKIN PATCH FROM XYLOGLUCAN CONTAINED CAPSICUM EXTRACT FOR PAIN RELIEF. |
| By |
: JITTIMA UPALA AND SUPHIT KITTIPHITTHAYAKORN |
| Degree |
: DOCTOR OF PHARMACY |
| Advisor |
: ASST. PROF. WARISADA SILA-ON, Ph.D AND
ASST. PROF. UTSANA PUAPERMPOONSIRI, Ph.D |
| Keywords |
: XYLOGLUCAN, CAPSAICIN, HPMC, PVA, PVM-MA |
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| The skin patches have various application in pharmaceutical area including transdermal drug delivery systems and facial mask for skin rejuvenation. For this research, xyloglucan acted as a film former regarding its nontoxicity, biodegradability, environmental friendly and simply film preparation. Objective= The objective of this research was to develop skin patch from xyloglucan for pain relief. Methods= Skin patch was prepared by film casting technique. Xyloglucan, HPMC and PVA used as film formers, blended with PVM-MA, an adhesive polymer, as 1=1 ratio with totally concentration of 3%w/w. Glycerin was used as a plasticizer. Capsicum extract was incorporated in polymer dispersion as the capsaicin content equivalent to 0.0125-0.075 %w/w. Skin patches were dried using hot air oven at 50 °C for 6-8 hr. The physical, mechanical properties including capsaicin releasing from skin patch were performed. Results= Xyloglucan skin patch was opaque while that of HPMC was clear. Xyloglucan skin patches had poor tensile strength and adhesive strength as comparing to those of HPMC skin patches. However, they were more elasticity. The capsaicin content in capsicum extract and xyloglucan skin patch were 3.952 %w/v and 0.04 mg/cm2 respectively. Cumulative capsaicin content released from xyloglucan skin patch (54.30%) at 9 hr. was more than that from HPMC. Identification of functional group of capsaicin and skin patches by FT-IR found peak at wavenumber of 3330.63 cm-1, 3354.31 cm-1, respectively. These revealed the amide functional group of capsaicin (wavenumber 3250-3400 cm-1). Conclusion= Xyloglucan skin patch contained capsicum extract presented poor physical and mechanical properties than skin patch with synthetic polymer, but the active substance was more released. |
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