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Abstract |
| Title |
: DEVELOPMENT OF CURCUMIN/PIPERINE FLOATING
MICROPARTICLES FOR THE TREATMENT OF PEPTIC ULCER |
| By |
: NALINTIP NUANGHEMMARACH AND WIKANDA SEEPANBAL |
| Degree |
: DOCTOR OF PHARMACY |
| Advisor |
: ASSOC.PROF. WANDEE RUNGSEEVIJITPRAPA, PH.D. AND SUREEWAN DUANGJIT, PH.D. |
| Keywords |
: CURCUMIN, PIPERINE, MICROPARTICLE, FLOATING SYSTEM, PEPTIC ULCER |
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| Peptic ulcer is one of the major gastric diseases with relatively high mortality rate that caused by several factors such as Helicobactor pylori that has been reported that more than 50% of the world population. (Suriyajan and Trakulpua, 2012) Natural oils and plant extracts can replacement of antibiotics and Innovation of drug delivery system may also enhance the treatment. Objective= develop curcumin and piperine floating microparticles for the treatment of peptic ulcer. Methods= Microparticles were prepared by solvent evaporation method. Ethylcellulose was used as wall material in the range of
90-110 mg/ml of solvent. Development of floating system is based on the use of low density coconut oil encapsulated. Effect of formulation parameters on morphology, shape, size of microparticle, percentage entrapment, floating time and percentage of in vitro drug release was investigated. Results= The obtained microparticles exhibited spherical shape and processed size in the range of 200-500 micrometer depending on the ethylcellulose and oil concentration. Percentage entrapment were varied between 20-90%. Floating time over 72 hours in vitro and drug released was in a controlled release manner. Conclusions= Results from this study indicated that optimization of formulation could give desired floating microparticles could be potentially benefit for the treatment of peptic ulcer. |
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