| The objective of the present study was todevelop the dried powder of self-emulsifying drug delivery system of poorly water soluble drug and used Ibuprofen as a model drug. The desirable formula composed of 0.4 g Ibuprofen and 1=1 ratio of medium chain triglyceride (TricaprylinandLexol GT 865) and Polysorbate 80 which acted as oil phase and surfactant, respectively. As the SEDDS were dispersed in water, the small emulsions were rapidly formed giving the droplet size approximately 62-74 nanometer with the narrow size distribution (polydispersity index 0.175-0.210). Two approaches were used for conducting the solid SEDDS= the adsorption on the solid carriers and solid dispersion with Polyethylene glycol (PEG). In case of the adsorption of SEDDS on the solid carrier (AdSEDDS), it was found that Silicon dioxide showed the highest adsorpability but the flowability of the obtained powder was poor as compared with that of Veegum. The solid dispersion with PEG 6000 and 3350 (SSEDDS) prepared using the fusion method. The XRD patterns of the pure drug presented the crystalline structure with intense particular peaks but missing in the pattern of SSEDDS. These demonstrated that the drug molecules were dissolved in the PEG matrix of the amorphous structure. In addition, DSC thermogram of the AdSEDDS and SSEDDS showed the characteristic peak of the solid carriers and PEG matrix without a drug peak, indicating that the drug had completely changed into an amorphous structure. For the in vitro dissolution testing, the capsules containing SSEDDS illustrated the remarkable enhancement in the dissolution profile compared with that of AdSEDDS, the physical mixture and drug alone. In conclusion, the solid adsorbents and PEG solid dispersion incorporating SEDDS could improve the dissolution of poorly water soluble drug by modifying the microstructure of drug and forming a nanoemulsion or solubilizing particles when exposed to the dispersing medium. |