Abstract

Title :

The study of Hyponatremia in patients receiving psychotropic drugs

By :

Chawanakorn Philakul

Jirawit Yodwandee

 

Degree : DOCTOR OF PHARMACY
Advisor :

Chompoonuch Weerawattanachai 

 Sipanut Silaket

Tuanthon Boonlue 

Keywords :

Hyponatremia, Psychotropic drugs

   

Introduction: Hyponatremia is defined as serum sodium below 135 mEq/L. Hyponatremia is a common electrolyte disorder in psychiatric patients. Factors affecting are the use of psychotropic drugs and other factors such as gender, age, underlying diseases, etc. Materials and Methods: This study was retrospective cross-sectional study. Data collection was conducted in psychiatric inpatients at Prasrimahabhodi psychiatric hospital using medical records between January 1, 2560 and December 31, 2561. Inclusion criteria was psychiatric patients who older than 18 years old ,use of psychotropic drugs and had serum sodium measurement. Using descriptive statistics to describe the prevalence of psychotropic drugs-induced hyponatremia and Chi- square statistics to determine the correlations between use of psychotropic drugs and hyponatremia. Results: Psychiatric inpatient with serum sodium measurement in study period were 2,257 and 199 patients had hyponatremia. The prevalence of hyponatremia in patients receiving psychotropic drugs was 3.32% (84/2527). Psychotropic drugs that associated with hyponatremia including First generation antipsychotics , Second generation antipsychotics , Mood Stabilizers, Selective serotonin reuptake inhibitors, Atypical Antidepressants, Tricyclic antidepressants. The main strategy for management of psychotropic drugs-induced hyponatremia was follow sign and symptoms without discontinuation drug. Conclusions: the prevalence of hyponatremia in patients receiving psychotropic drugs was 3.32 and almost all psychotropic drug can cause hyponatremia. 

   
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