Abstract

Title :

Synthesis of (E)-1-(3¢,4¢-dimethoxyphenyl)butadiene and one-pot extraction and encapsulation of the synthesized compound in cyclodextrin as rapidly dissolved powder for pharmaceutical use

By :

Mattaka Janmuang

 Pongpak Kongpo

Degree : DOCTOR OF PHARMACY
Advisor :

Bancha Yingngam 

Keywords :

Artificial neural neywork, Cyclodextrin, (E)-1-(3¢,4¢ dimethoxyphenyl)

Butadiene, Extraction, Green chemistry, Response surface methodology

   

Introduction: (E)-1-(3¢,4¢-dimethoxyphenyl)butadiene (DMPBD) is a potent anti-inflammatory agent in Zingiber montanum rhizomes. Some of the drawbacks of conventional extraction techniques impede its commercialization. This study was conducted to model and optimize the one-pot green extraction and encapsulation of DMPBD in hydroxypropyl-b-cyclodextrin (HP-b-CD). Methods: A Response Surface Methodology (RSM) and an Artificial Neural Network (ANN) approach were implemented as an innovative tool coupled with microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). The effects of the recovery efficiency of DMPBD by HP-b-CD of either MAE or UAE operating conditions were analyzed in-depth. Results: DMPBD was successfully synthesized in our laboratory. The second-order model of the RSM agreed with the experimental results. A Feed-Forward Back-Propagation Neural Network model was developed. Different training algorithms were evaluated and the Levenberg Marquardt method was selected as the best one. Ten neurons in the hidden layer generated the highest determination coefficient, and lowest root mean square error and absolute average deviation. The results of the genetic algorithm, which established the optimal conditions for extraction, demonstrated that applying HP-b-CD improves DMPBD recovery. The predicability of the RSM and ANN models was almost identical. The MAE offered better extraction performance compared to the UAE. Conclusions: Our findings demonstrate the feasibility of extracting and encapsulating the target DMPBD from Z. montanum in HP-b-CD. These green and efficient processes should be a promising option to guide the industrial design of fast-dissolved powders containing DMPBD.

   
Close this window