Abstract

Title : RICE BRAN OIL IN NANO-STRUCTURE LIPID CARRIER (NLC) FOR IMPROVED SKIN HYDRATION
By : RODJAREKHA WANNASRI SIRINAN PHUTTHALA SUNIDA KHAMHA
Degree : BACHELOR OF PHARMACY
Advisor : WANDEE RUNGSEEVIJITPRAPA ZONGPORN JOUNGMUNKONG
Keywords : NANOSTRUCTURE LIPID CARRIER (NLC), RICE BRAN OIL, %ENCAPSULATION
   
The purpose of this study was to develop rice bran oil nanostructure lipid carrier (NLC) for skin hydration. NLC were prepared by hot melt homogenization method. Compritol® ATO 888 and Pluronic® F 68 were employed as lipidic material and non-ionic emulsifier, respectively. As a comparison, niosomes were prepared by Chloroform film method. Physical stability of rice bran oil NLC and niosomes were investigated by measuring particle size and zeta potential. Encapsulation efficiency of the rice bran oil in NLC and nisomes were investiagted by indirect method. Gamma oryzanol was used as a standard marker and its content was analyzed by high performance liquid chromatography. Physical characteristics of the NLC-enriched cream underwent accelerated-stability study by heating-cooling cycling remained unchanged. Thus the formulation was expected to be stable in 2 years at room temperature. The satisfaction was investigated in 30 healthy volunteersy by questionnaires after applied cream product. Results showed NLC formulations with compritol= rice bran oil ratio of 4=6 was the most stable system with mean particle size and zeta potential ranging from 166 to 353 nm and -31.5 mV to -14 mV, respectively. Entrapment efficiency of γ-oryzanol in NLC was 61.87%. After application of the NLC-RBO formulations 26.67% of human volunteers were very satisfactory. In conclusions, rice bran oil encapsulation in NLC represents a promising cosmetic delivery for skin hydration.
   
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