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Abstract |
| Title |
: Development of combined herbal tablets, Fah Talai (Andrographis paniculata) and mangosteen (Garcinia mangostana) for the treatment of diarrhea. |
| By |
: Thunyatip Chantornpasit
Pichamon Tangsiriwattanakul
Wanvisa Rattanapanadda |
| Degree |
: BACHELOR OF PHARMACY |
| Advisor |
: Benjaphorn Sethabouppha
Oranuch Thanakatepaisarn
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| Keywords |
: Fah-Talai, Andrographis paniculata, mangosteen, Garcinia mangostana, Herbal tablets |
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| Andrographolide, a major substance found in Fah-Talai (Andrographis paniculata) inhibits the growth of bacteria that causes diarrhea in human gut. However, Andrographolide has no effect on secretion in neither intestine nor bowels. To get good result in diarrhea treatment, tannin, compounds found in mangosteen peel, a well known astringent, was selected to use in this study. This research was aimed to develop a combined herbal tablets, mangosteen (Garcinia mangostana) and Fah-Talai (Andrographis paniculata) for the treatment of diarrhea. Fah-Talai and mangosteen peels were separately extracted with 95% ethanol and was concentrated using rotary evaporator. The concentrated extracts were tested for the microbial inhibitory activity using agar diffusion disk method. Results showed good relationship between Fah-Talai concentration and inhibition of E. coli. In contrast, there was no relationship between mangosteen extracts concentration and antimicrobial activity. The tablets of combined two herbs were prepared by wet granulation technique. Results from tablets properties tests (weight variation, disintegration time, friability, hardness and thickness) indicated that the obtained tablets were meet all USP 28 requirements. The amount of andrographolide and tannin per tablet were determined using HPLC and Ferric Chloride T.S. method respectively. The content of andrographolide found was 10.13 ± 0.24 mg and tannin was 21.68 ± 0.11 mg per tablet. The dissolution profile of andrographolide was also investigated. Result from dissolution test indicated that the andrographolide was released and almost reached the saturated point within 120 minute time. It could be concluded that the tablets prepared from this experiment achieved all requirements and should be further tests for its stability and in vivo test.
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