Abstract

Title : DEVELOPMENT OF PAPAIN NIOSOMES FOR HAIR REVITALIZATION
By : PARICHAT CHARATSAKUL THICHAGORN KERDSAI PATAMA LAODARAJAK
Degree : BACHELOR OF PHARMACY
Advisor : WANDEE RUNGSEEVIJITPRAPA
Keywords : PAPAIN ENZYME, PAPAYA RUBBER, NIOSOMES, HAIR REVITALIZATION, HAIR CONDITIONER
   
The objective of this study was to develop papain niosomes for hair revitalization. Niosomes were prepared by film hydration by varying different types of surfactants. Effect of papain loading on niosome size and percentage entrapment was investigated. Stability of formulations were performed at 37, 45, 60 °C. Dissolution of papain noisome was investigated in phosphate buffer pH 6.5 at 37 °C using dialysis bag. Results showed that the obtained niosomes size was in the range of 200-400 nm. The formulation had good stability at 4° C for at least 1 month. Papain enzyme was more slowly released from niosomes and gave less skin irritation than unencapsulated system. Picture from scanning electron microscope exhibited smooth cuticle hair surface after treated with papain niosmes. In contrast, hair cuticle following treatment of unencapsulated papain showed obvious cuticle damage. Efficiency of the formulation as well as skin irritation test in human volunteers was under investigated. In conclusion, papain encapsulated in niosomes could improve papain enzyme stability and reduced hair damage and scalp skin irritation. Therefore, papain encapsulated in niosomes incorporated into hair conditioner had good efficacy for hair revitalization and could potentially be developed as commercial product.
   
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