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Abstract |
| Title |
: THE EFFECT OF BLOOD PRESSURE CONTROL FROM SWITCHING FELODIPINE TO AMLODIPINE IN OUT-PATIENTS WITH HYPERTENSION AT SAPPRASITTHIPRASONG HOSPITAL,
UBON RATCHATHANI
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| By |
: TOONSAK PUNKATE, NIPARAT SANGKUL, PIYANUCH BOONTHUM |
| Degree |
: BACHELOR OF PHARMACY |
| Advisor |
: NONGLEK KUNAWARADISAI |
| Keywords |
: HYPERTENSION, FELODIPINE, AMLODIPINE,
ADVERSE DRUG REACTION
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| The objective of this retrospective study was to determine the effect of blood pressure control and adverse drug reactions from switching Felodipine to Amlodipine in out-patients with hypertension at Sapprasitthiprasong Hospital, Ubon Ratchathani. The data were collected from electronic database together with OPD cards of 76 hypertensive patients during January 2007 to May 2009.
The results revealed that blood pressure of subjects who switched from Felodipine 5 mg to either Amolodipine 5 mg or 10 mg were not significantly different [(SBP=127.38 10.34 mmHg vs. 128.78 13.24 mmHg; p = 0.489), (DBP = 73.73 9.36 mmHg vs. 72.53 10.14 mmHg; p = 0.533)]. Likewise, switching from Felodipine 10 mg to Amlodipine 10 mg or 20 mg resulted in the insignificant difference in blood pressure in any of those subjects [(SBP=126.33 10.45 mmHg vs. 135.33 12.69 mmHg ; p = 0.088), (DBP=69.67 13.99 mmHg vs. 74.80 9.82 mmHg; p = 0.136)].
In conclusion, these results indicated that switching from Felodipine to Amlodipine in patients with hypertension showed the indifferent in blood pressure control. In terms of adverse reactions, peripheral edema was the most frequently problem reported while on Amlodipine.
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